Currently, the widely used notion of activity is increasingly present in computer science. However, because this notion is used in specific contexts, it becomes vague. Here, the notion of activity is scrutinized in various contexts and, accordingly, put in perspective. It is discussed through four scientific disciplines: computer science, biology, economics, and epistemology. The definition of activity usually used in simulation is extended to new qualitative and quantitative definitions. In computer science, biology and economics disciplines, the new simulation activity definition (...) is first applied critically. Then, activity is discussed generally. In epistemology, activity is discussed, in a prospective way, as a possible framework in models of human beliefs and knowledge. (shrink)

Kết quả nghiên cứu đăc biệt có giá trị khoa học và thực tiễn khi kết quả cho thấy mạng lưới các nhà khoa học xã hội tại Việt Nam vẫn còn yếu và chưa bền vững.

Hàng năm, việc công bố danh sách các nhà nghiên cứu thuộc tốp 100 ngàn các nhà nghiên cứu có trích dẫn khoa học hàng đầu thế giới theo Cơ sở dữ liệu Scopus là vấn đề rất được cộng đồng khoa học quan tâm. -/- Năm 2021, kết quả này đã tiếp tục được công bố bởi nhóm tác giả gồm TS. John P. A. Ioannidis (giáo sư thực thụ về y khoa, nghiên cứu sức khỏe và chính sách, (...) khoa học dữ liệu y sinh và thống kê học thuộc Đại học Stanford, Mỹ), Jeroen Baas (giám đốc dữ liệu của Nhà xuất bản Elsevier, Hà Lan) và TS. Kevin Boyack (giám đốc điều hành của Công ty SciTech Strategies, Mỹ; chuyên về trắc lượng khoa học). -/- Việc sử dụng Cơ sở dữ liệu Scopus thuộc Nhà xuất bản Elsevier của Hà Lan làm cho kết quả của nhóm tác giả trở nên tin cậy và có ảnh hưởng sâu rộng trong cộng đồng khoa học thế giới bởi lẽ Scopus là một trong hai cơ sở dữ liệu khoa học uy tín nhất trên thế giới hiện nay, bên cạnh Cơ sở dữ liệu Web of Science của Mỹ. -/- Trong năm nay, nhóm tác giả trên công bố các danh sách các nhà nghiên cứu có trích dẫn khoa học cao thuộc tốp 100.000 hoặc tốp 2% trên toàn thế giới gồm xét theo thành tựu trọn đời, thành tựu năm gần nhất và thành tựu theo chuyên ngành. (shrink)

At a distance of more ten years from publication (2000 French/2005 English translation), with this essay I will re-read, comment and discuss, in different way and in form of anthological sketch, the Derridean volume ‘On Touching-Jean Luc Nancy’, focusing in particular on its ‘tangents and its metonymies’, its manifold entanglements with the metaphysics of touch and bodily connections. Making use of the geometrical figure of the tangent, Derrida affirms that "[if] philosophy has touched the limit [my emphasis-J. D. ]. of (...) the ontology of subjectivity, this is because philosophy has been led to this limit”. To touch is to touch a limit, a limit without depth or surface. How have we regarded touching in the past? The body? My thesis is that if Derridean reflection remains mostly anchored to Jean-Luc Nancy’s Corpus, it is inspired nevertheless by a different deconstructive gesture/s similar to different geometric tangents (the deconstructive practice is similar to the tracing of many tangents). Discussing in particular Nancy’s Dis-Enclosure: The Deconstruction of Christianity, Derrida’essay ‘Deconstruction of Christianity’ and devoting an entire section of the book to the sense of touch in the Gospels, Derrida gives us numerous and special considerations on deconstruction and the deconstruction of touch in Christianity, admitting as well the enormity of this task. A reflection on the Kas Saghafi, “Safe, Intact”: Derrida, Nancy, and the “Deconstruction of Christianity” will follow in an exemplary way. Following a discussion of touch and the body in both animal and human spheres, in the closing section of the essay, I will comment on the Patrick Llored’s essay A Philosophy of Touching Between the Human and the Animal: The Animal Ethics of Jacques Derrida, recently published in A Companion to Derrida (2014). This study addresses highly topical questions such as: ‘What does it teach us about touch, but also about the body and the life of the animal? To what extent is it capable of renewing our knowledge [connaissance] of non-human life and of generating an animal ethics reconceived from top to bottom? If touching is coextensive with the living body, that implies not only that we place the haptical question at the centre of reflection on the animal, but also that we take into account the consequence that is most disruptive for us today (A Companion, p. 512). And conclude along with Patrick Llored that the question of touch promises to transform everything we have understood until now about animality. (shrink)

Ngụ ngôn về ông bói cá cho biết ông là nhân vật khá tinh nghịch, có lúc ngớ ngẩn như trẻ con, nhưng nhiều khi không thiếu những lời triết lý cũng ra gì phết! Vậy nên tác giả bình sách N. P. Tri cho rằng, chuyện của ông dành cho cả trẻ em lẫn người đã trưởng thành cũng rất có lý. Ở một góc nhìn khác, tác giả D. T. M. Phượng lại nhận thấy một dịp để người (...) đọc đồng hành, phiêu lưu cùng với ông “triết gia Xóm Chim” để có thể đánh giá xem ông ấy ngẩn ngơ thật hay không. (shrink)

In their recently published book Nudge (2008) Richard H. Thaler and Cass R. Sunstein (T&S) defend a position labelled as ‘libertarian paternalism’. Their thinking appeals to both the right and the left of the political spectrum, as evidenced by the bedfellows they keep on either side of the Atlantic. In the US, they have advised Barack Obama, while, in the UK, they were welcomed with open arms by the David Cameron's camp (Chakrabortty 2008). I will consider the following questions. What (...) is Nudge? How is it different from social advertisement? Does Nudge induce genuine preference change? Does Nudge build moral character? Is there a moral difference between the use of Nudge as opposed to subliminal images to reach policy objectives? And what are the moral constraints on Nudge? (shrink)

Philosophers have not been very preoccupied by the link between emotions and attention. The few that did (de Sousa, 1987) never really specified the relation between the two phenomena. Using empirical data from the study of the emotion of fear, we provide a description (and an explanation) of the links between emotion and attention. We also discuss the nature (empirical or conceptual) of these links.

Utilitarianism, it has been said, is not sensitive to the distribution of welfare. In making risky decisions for others there are multiple sensitivities at work. I present examples of risky decision-making involving drug allocations, charitable giving, breast-cancer screening and C-sections. In each of these examples there is a different sensitivity at work that pulls away from the utilitarian prescription. Instances of saving fewer people at a greater risk to many is more complex because there are two distributional sensitivities at work (...) that pull in opposite directions from the utilitarian calculus. I discuss objections to these sensitivities and conclude with some reflections on the value of formal modelling in thinking about societal risk. (shrink)

I investigate whether any plausible moral arguments can be made for ‘grandfathering’ emission rights (that is, for setting emission targets for developed countries in line with their present or past emission levels) on the basis of a Lockean theory of property rights.

We construct a probabilistic coherence measure for information sets which determines a partial coherence ordering. This measure is applied in constructing a criterion for expanding our beliefs in the face of new information. A number of idealizations are being made which can be relaxed by an appeal to Bayesian Networks.

The Distribution View provides a model that integrates four distributional concerns in the evaluation of risky prospects. Starting from these concerns, we can generate an ordering over a set of risky prospects, or, starting from an ordering, we can extract a characterization of the underlying distributional concerns. Separability of States and/or Persons for multiple-person risky prospects, for single-person risky prospects and for multiple-person certain prospects are discussed within the model. The Distribution View sheds light on public health policies and provides (...) a framework for the discussion of Parfit's Priority View for risky prospects. (shrink)

I examine the relationship between belief and credences and distinguish between a dogmatic, a Lockean, an agentic, and an abductive notion of belief. I conclude with some thoughts on voluntarism and evidentialism.

The paper surveys the currently available axiomatizations of common belief (CB) and common knowledge (CK) by means of modal propositional logics. (Throughout, knowledge- whether individual or common- is defined as true belief.) Section 1 introduces the formal method of axiomatization followed by epistemic logicians, especially the syntax-semantics distinction, and the notion of a soundness and completeness theorem. Section 2 explains the syntactical concepts, while briefly discussing their motivations. Two standard semantic constructions, Kripke structures and neighbourhood structures, are introduced in Sections (...) 3 and 4, respectively. It is recalled that Aumann's partitional model of CK is a particular case of a definition in terms of Kripke structures. The paper also restates the well-known fact that Kripke structures can be regarded as particular cases of neighbourhood structures. Section 3 reviews the soundness and completeness theorems proved w.r.t. the former structures by Fagin, Halpern, Moses and Vardi, as well as related results by Lismont. Section 4 reviews the corresponding theorems derived w.r.t. the latter structures by Lismont and Mongin. A general conclusion of the paper is that the axiomatization of CB does not require as strong systems of individual belief as was originally thought- only monotonicity has thusfar proved indispensable. Section 5 explains another consequence of general relevance: despite the "infinitary" nature of CB, the axiom systems of this paper admit of effective decision procedures, i.e., they are decidable in the logician's sense. (shrink)

How much can we shape the emotions we experience? Or to put it another way, how plastic are our emotions? It is clear that the exercise of identifying the degree of plasticity of emotion is futile without a prior specification of what can be plastic, so we first propose an analysis of the components of emotions. We will then turn to empirical data that might be used to assess the degree of plasticity of emotions.

I argue that the post-1990 practice of giving leadership positions in companies to non-ex-communists is an example of affirmative action.

Belgium has recently extended its euthanasia legislation to minors, making it the first legislation in the world that does not specify any age limit. I consider two strands in the opposition to this legislation. First, I identify five arguments in the public debate to the effect that euthanasia for minors is somehow worse than euthanasia for adults—viz. arguments from weightiness, capability of discernment, pressure, sensitivity and sufficient palliative care—and show that these arguments are wanting. Second, there is another position in (...) the public debate that wishes to keep the current age restriction on the books and have ethics boards exercise discretion in euthanasia decisions for minors. I interpret this position on the background of Velleman’s “Against the Right to Die” and show that, although costs remain substantial, it actually can provide some qualified support against extending euthanasia legislation to minors. (shrink)

In this introduction, we give a brief overview of the main concepts of modularity that have been offered in recent literature. After this, we turn to a summary of the papers collected in this volume. Our primary aim is to explain how the modularity of emotion question relates to traditional debates in emotion theory.

Choice often proceeds in two stages: We construct a shortlist on the basis of limited and uncertain information about the options and then reduce this uncertainty by examining the shortlist in greater detail. The goal is to do well when making a final choice from the option set. I argue that we cannot realise this goal by constructing a ranking over the options at shortlisting stage which determines of each option whether it is more or less worthy of being included (...) in a shortlist. This is relevant to the 2010 UK Equality Act. The Act requires that shortlists be constructed on grounds of candidate rankings and affirmative action is only permissible for equally qualified candidates. This is misguided: Shortlisting candidates with lower expected qualifications but higher variance may raise the chance of finding an exceptionally strong candidate. If it does, then shortlisting such candidates would make eminent business sense and there is nothing unfair about it. This observation opens up room for including more underrepresented candidates with protected characteristics, as they are more likely to display greater variance in the selector’s credence functions at shortlisting stage. (shrink)

In the novel "Het Been" by the Flemish writer Willem Elsschot. In the novel, a businessman becomes obsessive over the fact that a victim of his unscrupulous business practices refuses to forgive him. This raises the following questions: Why does one find it upsetting when the victim of one's wrongdoing refuses to accept our apologies? Why does one find it upsetting when the victim is unwilling to grant us the forgiveness that we are asking for?

Some of the challenges in Sanders et al. (this issue) can be aptly illustrated by means of charity nudges, that is, nudges designed to increase charitable donations. These nudges raise many ethical questions. First, Oxfam’s triptychs with suggested donations are designed to increase giving. If successful, do our actions match ex ante or ex post preferences? Does this make a difference to the autonomy of the donor? Second, the Behavioural Insights Team conducted experiments using social networks to nudge people to (...) give more. Do these appeals steer clear of exploiting power relations? Do they respect boundaries of privacy? Third, in an online campaign by Kiva, donors are asked to contribute directly to personalized initiatives. In many cases, the initiative has already been funded and donor money is funnelled to a new cause. Is such a “pre-disbursal” arrangement truthful and true to purpose as a social business model? (shrink)

This is a transcript of a conversation between P F Strawson and Gareth Evans in 1973, filmed for The Open University. Under the title 'Truth', Strawson and Evans discuss the question as to whether the distinction between genuinely fact-stating uses of language and other uses can be grounded on a theory of truth, especially a 'thin' notion of truth in the tradition of F P Ramsey.

Considerations of objective-value freedom and status freedom do impose constraints on policies that restrict access to cigarettes. As to the objective-value freedom, something of value is lost when anti-alcohol policies lead to pub closures interfering with valued life styles, and a similar, though weaker, argument can be made for cigarettes. As to status freedom, non-arbitrariness requires consultation with vulnerable populations to learn what might aid them with smoking cessation.

Risky prospects represent policies that impose different types of risks on multiple people. I present an example from food safety. A utilitarian following Harsanyi's Aggregation Theorem ranks such prospects according to their mean expected utility or the expectation of the social utility. Such a ranking is not sensitive to any of four types of distributional concerns. I develop a model that lets the policy analyst rank prospects relative to the distributional concerns that she considers fitting in the context at hand. (...) I name this model ‘the Distribution View’ posing an alternative to Parfit's Priority View for risky prospects. (shrink)

Kant's aim in the transcendental deduction is to show that the categories, i.e., a specific set of categories, are a necessary condition for all possible experience. Some philosophers have extended this idea in the following way: Kant solely identified a set of a priori concepts, which are a necessary condition for all possible epistemic claims within a framework of Newtonian physics; however, there exist other sets of epistemic claims, which can solely be justified by means of alternative sets of a (...) priori concepts. In this paper I will address the following questions: (1) What claims are precisely involved in this alleged extension of Kant's results of the transcendental deduction? (2) Is it merely an historical accident that Kant could only identify one set of categories, or, are there, apart from Kant's explicit commitment to one particular set of categories, any other claims within the Transcendental Analytic, which are incompatible with this extension of Kant's view? (shrink)

There are three slogans in the history of Socialism that are very close in wording, viz. the famous Cabet-Blanc-Marx slogan: "From each according to his ability; To each according to his needs"; the earlier Saint-Simon-Pecqueur slogan: "To each according to his ability; To each according to his works"; and the later slogan in Stalin’s Soviet Constitution: "From each according to his ability; To each according to his work." We will consider the following questions regarding these slogans: a) What are the (...) earliest occurrences of each of these slogans? b) Where does the inspiration for each half of each slogan come from? c) What do the Saint-Simonians mean by “To each according to his ability”? d) What do they mean by “To each according to his works”? e) What motivates the shift from “To each according to his ability” to “From each according to his ability”? f) How should we envisage the progression toward “To each according to his needs”? g) What is the distinction between from “To each according to his works” and “To each according to his work”? (shrink)

In this commentary on Yashar Saghai's article "Salvaging the Concept of Nudge" (JME 2013) I discuss his distinction between a 'prod' (which is 'substantially controlling') and a 'nudge' (which is ‘substantially non-controlling’).

Socrates’ eros model, St. Paul’s agape model, and Aristophanes’ shared-identity model have different takes on the constancy of love and on the loss of love. I illustrate how these models and themes find expression within literature, music, and film through the ages.

I argue in this paper that there are two considerations which govern the dynamics of a two-person bargaining game, viz. relative proportionate utility loss from conceding to one's opponent's proposal and relative non-proportionate utility loss from not conceding to one's opponent's proposal, if she were not to concede as well. The first consideration can adequately be captured by the information contained in vNM utilities. The second requires measures of utility which allow for an interpersonal comparison of utility differences. These considerations (...) respectively provide for a justification of the Nash solution and the Kalai egalitarian solution. However, none of these solutions taken by themselves can provide for a full story of bargaining, since, if within a context of bargaining one such consideration is overriding, the solution which does not match this consideration will yield unreasonable results. I systematically present arguments to the effect that each justification from self-interest for respectively the Nash and the Kalai egalitarian solution is vulnerable to this kind of objection. I suggest that the search for an integrative model may be a promising line of research. (shrink)

The novelty in Adam Burgess’ paper is that he assesses nudge policies in the context of the shift in the UK government’s approach to risk from the nannying policies of Labour to the nudge policies of the Conservatives. There is a wealth of ideas in this paper. I find it useful to disentangle some of these ideas focusing on the following two questions: 1. In what respects do Labour’s nannying policies and the Conservatives’ nudge policies differ? 2. What is problematic (...) about Labour’s nannying and the Conservatives’ nudge policies? Subsequently I will reflect on how a particular strand of research in the social sciences can be made relevant to designing a more responsible way of dealing with societal risk and show how this approach can evade some of Burgess’ concerns. (shrink)

This chapter contains sections titled: Going Beyond Nature in Order to Explain it Technē, epistēmē and alēthēs doxa Mathematics, pure and applied Observation and Experimental Verification Bibliography.

I argue that by constructing an identity of Bohemian whim and spontaneity one can make what was previously an akratic action into a fully rational action, since in performing the action, one asserts one identity.

At the heart of Drazen Prelec’s chapter is the distinction between outcome utility and diagnostic utility. There is a particular distinction in the literature on causal networks (Pearl 2000), namely the distinction between observing and intervening, that maps onto Prelec’s distinction between diagnostic and outcome utility. I will explore the connection between both frameworks.

Many religions offer hope for a life that transcends death and believers find great comfort in this. Non-believers typically do not have such hopes. In the face of death, they may find consolation in feeling contented with the life they have lived. But do they have hopes? I will identify a range of distinctly secular hopes at the end of life. Nothing stops religious people from sharing these secular hopes, in addition to their hope for eternal life. I will distinguish (...) between hopes about one’s life, hopes about one’s death, hopes about attitudes of others, and hopes about the future. But before turning to these hopes, I will reflect on the following question: What is it that would keep a person from hoping for eternal life? (shrink)

I illustrate the use of decision-theory and game-theory in the social sciences by means of examples from Gauthier, Tversky and Kahneman, and Bouldon.

"The Personal is Political": This was an often-heard slogan of feminist groups in the late sixties and early seventies. The slogan is no doubt open to many interpretations. There is one interpretation which touches on the epistemology of social facts, viz. the slogan claims that in assessing the features of a political system, personal experiences have privileged evidentiary value. For instancte, in the face of third person reports about political corruption, I may remain unmoved in my belief that the political (...) powers are morally upstanding, and it is only when I myself am adversely affected, that I come to change my views. There are two standard patterns of explanation of this type of belief formation: (i) We know that third-person reports may be lessreliable than first-person experiences; (ii) If the third-person reports are no less reliable than first-person experiences, we may just be dealing with a standard pattern of epistemic irrationality. However, we argue that there is also a much more surprising pattern of explanation: under certain conditions, a Bayesian argument can be proffered to the effect that it is rational to change one's beliefs in the face of personal experiences and not in the face of third-person reports, even if these experiences and reports are equally reliable. Hence, the feminist slogan (at least on one particular interpretation of it) receives unexpected support from Bayesian comers. We also show that this pattern of explanation has surprising repercussions on the question of the evidentiary value of miracles in philosophy of religion. (shrink)

In decision-theory, the notion of regret enters into the minimax decision-rule and has a determinate usage in this context. However, there are many alternative ways of conceiving of regret. The chapter constructs the einmalist- nicht-keinmal ('once is not never') game, in which a single sampling radically changes the expected value of the game in a way that is quite counterintuitive, as the basis for studying regret after a loss following the choice of an uncertain action. Crucially, the very loss affects (...) the posterior expectation of the game and the posterior credence about the objective chances of a win. Our taxonomy of regret contains regret over the action chosen and regret over the outcome obtained as its main categories, and is mirrored by a taxonomy of joy after a win following the choice of an uncertain action, and is used to critique of Krähmer and Stone's analysis of risk aversion for uncertain actions. (shrink)

Dans cet article, je considère l’influence possible des recherches récentes sur les attitudes en psychologie sociale, principalement dans le paradigme des théories des processus duaux [dual process theories], sur notre compréhension de la responsabilité. La thèse que je soutiens est que certaines révisions à notre façon de comprendre la responsabilité et nos pratiques d’attribution de la responsabilité pourraient être justifiées par ces travaux. Avant de présenter les révisions que j’introduis, je décris les grandes lignes du paradigme que j’utiliserai, soit celui (...) des théories processus duaux tel qu’appliqué aux attitudes. Puis, m’inspirant de Vargas (2004, 2005), je présente les différentes formes que peuvent prendre le révisionnisme. Parce que ces révisions s’appliquent à des notions qui sont utilisées à la fois par le commun des mortels et par les philosophes (qui tentent soit de les reconstruire rationnellement, soit de les modifier), je présente ce que l’on présume que pense chacun des groupes sur la question. Finalement, je présente trois révisions, plutôt « locales », que ces travaux pourraient inspirer. (shrink)

I argue that we can generate intransitive preference orderings for a single person on the model of Sen's Libertarian Paradox.

It is important in its own right to determine what conception of mutual disinterest Rawls has in mind at the various junctions in the text. Furthermore, disambiguating this notion counters a common objection that there is no reason to accept principles of justice that are chosen by rational egoists. The persons in Rawls' OP are not rational egoists. Rather, in identifying with the token persons in society they make the actual interests of the token persons into their ends and they (...) know that they are choosing principles of justice for a society in which moderate selfishness reigns. But this is very remote from stipulating a selfish disposition for the persons in the OP. Hence, the objection is contingent on a natural misreading of Rawls' notion of mutual disinterest and can be readily dispelled by disambiguating this notion into a motivational and an epistemic constraint on the OP. (shrink)

We discuss theoretical topics in personality theory and in the methodology of personality measurement, and present personality tests that were developed in the Center for Recruitment and Selection in the Belgian Army.

This paper will show that Mary Wollstonecraft developed a modern feminist version of virtue ethics. Virtue ethics is an all-encompassing moral theory which holds that the best life for individuals is commensurate with a good society. Simply, self-interest and our public duties are argued as identical and not at odds when we realize what is truly good for ourselves and for others. In the Western philosophic cannon, the most common version of virtue ethics is Aristotle’s, with the Nicomachean Ethics as (...) the definitive presentation. Wollstonecraft’s argument for the political, social, economic, and personal equality of women utilizes ideas that are reminiscent of classical virtue ethics. Her novel and effective addition is to show that the explicit inclusion of women requires a reconsideration of the duties needed for happy lives to be led and for a good society, and good families, to exist. (shrink)

The Dominican theologian Durand of Saint-Pourçain (ca. 1275–1334), breaking from the wide consensus, made a two-pronged attack on concurrentism (i.e., the theory according to which God does more than conserving creatures in existence and co-causes all their actions). On the one hand, he shows that the concurrentist position leads to the unacceptable consequence that God is the direct cause of man’s evil actions. On the other hand, he attacks the metaphysical foundations of concurrentism, first in the version offered by Thomas (...) Aquinas and Giles of Rome, and then in a more general way. Against Thomas and Giles, he challenges Neoplatonic assumptions about causality and being. More generally, he establishes that God’s action and a creature’s action can be neither identical nor different, and thus cannot both be direct causes of the same effect. Without claiming that Durand’s series of objections are definitely unanswerable, we may at least observe that they have generally been underestimated (which earned him the lowly role of the mere foil of the concurrentist view in the history of philosophy) and are able to do considerable damage to concurrentism. (shrink)

In this lyrical meditation on listening, Jean-Luc Nancy examines sound in relation to the human body. How is listening different from hearing? What does listening entail? How does what is heard differ from what is seen? Can philosophy even address listening, écouter, as opposed to entendre, which means both hearing and understanding? Unlike the visual arts, sound produces effects that persist long after it has stopped. The body, Nancy says, is itself like an echo chamber, responding to music by inner (...) vibrations as well as outer attentiveness. Since “the ear has no eyelid” (Quignard), sound cannot be blocked out or ignored: our whole being is involved in listening, just as it is involved in interpreting what it hears. The mystery of music and of its effects on the listener is subtly examined. Nancy’s skill as a philosopher is to bring the reader companionably along with him as he examines these fresh and vital questions; by the end of the book the reader feels as if listening very carefully to a person talking quietly, close to the ear. (shrink)

The aim of this paper is to assess the relevance of somatic evolution by natural selection to our understanding of cancer development. I do so in two steps. In the first part of the paper, I ask to what extent cancer cells meet the formal requirements for evolution by natural selection, relying on Godfrey-Smith’s (2009) framework of Darwinian populations. I argue that although they meet the minimal requirements for natural selection, cancer cells are not paradigmatic Darwinian populations. In the second (...) part of the paper, I examine the most important examples of adaptation in cancer cells. I argue that they are not significant accumulations of evolutionary changes, and that as a consequence natural selection plays a lesser role in their explanation. Their explanation, I argue, is best sought in the previously existing wiring of the healthy cells. (shrink)